Qingzhong Hu Selected Research

Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)

1/2019	Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing.
1/2017	Lead Optimization Generates CYP11B1 Inhibitors of Pyridylmethyl Isoxazole Type with Improved Pharmacological Profile for the Treatment of Cushing's Disease.
11/2016	Therapeutic compounds for Cushing's syndrome: a patent review (2012-2016).
9/2014	Potent 11β-hydroxylase inhibitors with inverse metabolic stability in human plasma and hepatic S9 fractions to promote wound healing.
8/2013	Cushing's syndrome: development of highly potent and selective CYP11B1 inhibitors of the (pyridylmethyl)pyridine type.
7/2012	Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing's syndrome.
8/2010	Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.

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Qingzhong Hu Research Topics

Disease

10	Prostatic Neoplasms (Prostate Cancer) 01/2019 - 08/2008
9	Cardiovascular Diseases (Cardiovascular Disease) 01/2019 - 01/2012
4	Breast Neoplasms (Breast Cancer) 01/2022 - 08/2012
4	Cushing Syndrome 01/2019 - 07/2012
4	Heart Failure 01/2015 - 06/2014
4	Fibrosis (Cirrhosis) 01/2015 - 06/2014
3	Hypertension (High Blood Pressure) 01/2015 - 06/2014
2	Neoplasms (Cancer) 01/2019 - 01/2019
1	Pituitary ACTH Hypersecretion 01/2017
1	Neuroendocrine Tumors (Neuroendocrine Tumor) 11/2016
1	Ectopic ACTH Syndrome 11/2016
1	Glucose Metabolism Disorders 01/2016
1	Hyperglycemia 01/2016
1	Insulin Resistance 01/2016
1	Wounds and Injuries (Trauma) 09/2014
1	Ventricular Remodeling 06/2014
1	Diabetic Nephropathies (Diabetic Nephropathy) 06/2014
1	Chronic Disease (Chronic Diseases) 06/2014
1	Heart Diseases (Heart Disease) 01/2014
1	Neoplasm Metastasis (Metastasis) 07/2013
1	Carcinoma (Carcinomatosis) 06/2010
1	Experimental Arthritis 12/2009

Drug/Important Bio-Agent (IBA)

10	Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA 01/2019 - 08/2008
8	AldosteroneIBA 01/2019 - 01/2012
7	Cytochrome P-450 CYP11B2 (CYP11B2)IBA 01/2019 - 01/2012
7	Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)IBA 01/2019 - 08/2010
6	AndrogensIBA 01/2016 - 07/2009
4	abirateroneIBA 01/2016 - 07/2009
3	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2019 - 09/2014
3	Aromatase (CYP19)IBA 01/2019 - 08/2012
3	Pharmaceutical PreparationsIBA 01/2019 - 03/2013
2	Mixed Function Oxygenases (Monooxygenases)IBA 01/2019 - 01/2014
2	LyasesIBA 01/2014 - 03/2013
2	Estrogens (Estrogen)FDA Link 01/2013 - 08/2012
1	Interleukin-6 (Interleukin 6)IBA 01/2022
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2019
1	pevonedistatIBA 01/2019
1	EnzymesIBA 01/2019
1	IsoxazolesIBA 01/2017
1	GlucocorticoidsIBA 11/2016
1	Glucagon (Glukagon)FDA Link 01/2016
1	3- hydroxy- 17- (1H- benzimidazole- 1- yl)androsta- 5,16- dieneIBA 01/2016
1	orteronelIBA 01/2016
1	Glucose (Dextrose)FDA LinkGeneric 01/2016
1	Insulin (Novolin)FDA Link 01/2016
1	ElectrolytesIBA 06/2014
1	MineralocorticoidsIBA 06/2014
1	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2014
1	SteroidsIBA 01/2014
1	Abiraterone AcetateIBA 01/2014
1	Docetaxel (Taxotere)FDA Link 01/2014
1	pyridineIBA 08/2013
1	Androgen Receptor AntagonistsIBA 07/2013
1	sipuleucel-T (APC8015)FDA Link 07/2013
1	enzalutamideIBA 07/2013
1	cabazitaxel FDA Link 07/2013
1	Denosumab FDA Link 07/2013
1	Cytotoxins (Cytolysins)IBA 07/2013
1	VaccinesIBA 07/2013
1	RadiopharmaceuticalsIBA 07/2013
1	RANK LigandIBA 07/2013
1	Aromatase InhibitorsIBA 01/2013
1	imidazoleIBA 06/2010
1	diphenyl (biphenyl)IBA 06/2010
1	FluorineIBA 06/2010
1	Therapeutic UsesIBA 12/2009

Therapy/Procedure

5	Therapeutics 01/2019 - 07/2010
3	Castration 01/2016 - 07/2013
1	Drug Therapy (Chemotherapy) 01/2014